21 results
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... • IV Fluids Shift ... (if preserved renal ... peaks 1-2h) • Blood ... #management #potassium
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... Benyzlpenicillin, blood ... differential #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Potassium Excretion ... happypillsrx/ #Hyperkalemia ... #Pathophysiology ... #Pharmacology # ... #Renal
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Clenching of fist during ... Crush injury • Blood ... • Recent IV potassium ... Intracellular Shift ... Blood transfusion
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Clenching of fist during ... Crush injury • Blood ... • Recent IV potassium ... Intracellular Shift ... Blood transfusion
ACEI Antihypertensive Dose Comparison. Consider divided (BID) regimen for better pre-dose (trough) BP control for the
Monitor BP, potassium ... , and renal function ... ACEInhibitor #ACEIs #Dosing ... #Conversion #Pharmacology ... #Hypertension #Management
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Diagnosis and Management ... Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Framework and Management ... UA positive for blood ... Shift of extracellular ... Monitor potassium ... Differential #Diagnosis #Management
Causes of Hyperkalemia
Pseudohyperkalemia
 - Tourniquet use
 - Hemolysis (in vitro)
 - Leukocytosis
 - Thrombocytosis
Intra- to extracellular
Causes of Hyperkalemia ... shift - Acidosis ... Transfusion of aged blood ... excretion - Renal ... acidosis) #Hyperkalemia
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
salt-losing tubulopathies ... Normal or low blood ... (renal potassium ... diagnosis #nephrology #management ... #pathophysiology