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differential hyperkalemia nephrology treatment algorithm table blood comparison criticalcare foamed hematology pathophysiology product reactions rhabdomyolysis anesthesia anesthesiology binders binding cardiac
Causes of Hyperkalemia Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
Causes of Hyperkalemia ... potassium intake ... transcellular shifts ... renal function, medication ... dysfunction is common #Diagnosis
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 Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC shift ... #differential #diagnosis ... pathophysiology #pharmacology ... #potassium #medications
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... ); nausea, vomiting ... patients sensitive to high ... of aspiration #Potassium ... #medications #pharmacology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... Medications 2. ... #causes #potassium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... Medications 2. ... #causes #potassium
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
Hyperkalemia Management ... • Treat the cause ... and parenteral potassium ... Intracellular K+ Shift ... #high
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... Dialysis Serum potassium ... blocks, QRS axis shift ... #potassium #high ... #diagnosis #management
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
- Shift from extracellular ... - Insulin (high ... hypomagnesemia #Medications ... #differential #diagnosis ... #nephrology #Causes
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... intracellular calcium causes ... - Hyperkalemia ( ... high potassium levels ... Pathophysiology #cardiology
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
Causes of Hyperkalemia ... Framework • Cellular Shift ... hyperosmolality - Medications ... #Causes #potassium ... #high
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