62 results
Treatment of hyperkalemia via kaliuresis 
step 1 = volume resuscitation if hypovolemic
step 2 = consider fludrocortisone
step
Treatment of hyperkalemia ... fludrocortisone step 3 = diuretic ... determine response to diuretic ... #treatment #diuretics ... #diuresis #nephrology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Transcellular Shift ... Thyrotoxicosis Medications ... Transcellular shifts ... • Discontinued diuretic ... nephrology #low #potassium
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts ... plasma insulin (treatment ... thiazide-like diuretics ... Postobstructive diuresis ... , Osmotic diuresis
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... Thiazides-type diuretics ... Metolazone) 5) Potassium-sparing ... diuretics (e.g. ... pharmacology #nephrology #medications
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... empagliflozin LOOP DIURETICS ... DIURETICS • Spironolactone ... Tolvaptan #Diuretics ... #Medications #Pharmacology
Hypokalemia Differential Diagnosis Algorithm

Low intake 
• poor oral intake 

Renal loss 
• Medication 
• Hypomagnesemia 
•
Hypokalemia Differential ... Renal loss • Medication ... Hypomagnesemia • Osmotic diuresis ... Transcellular shift ... Hypothermia • Hypokalemic
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... minutes) Decrease potassium ... • IV Fluids Shift ... function) - Loop diuretic ... LouLectures #Hyperkalemia
Diuresis in Critical Care - Achieving a Negative Fluid Balance
Advantages Of A Negative Fluid Balance:
 •
Diuresis in Critical ... CONCENTRATION MEDICATIONS ... , address diuretic ... ) to normalize Potassium ... Balance #management #criticalcare
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
- Shift from extracellular ... foscarnet - Diuretics ... and other loop diuretics ... antiretroviral therapy - Diuretics ... hypomagnesemia #Medications
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
the basis of the potassium-to-creatinine ... creatinine) • Cell shift ... Urine Cl - Loop diuretics ... , Thiazide diuretics ... #urine #potassium