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hyperkalemia management comparison nephrology table binding cardiology diagnosis digoxin effects hypotension kbinder kdigo lactated lr medications normal ns orthostatic pathophysiology
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
Binder INDICATION ... : Treatment of Hyperkalemia ... binder that can ... #Binder #KBinder ... Pharmacology
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
calcium for K; also binds ... nonspecifically binds ... patients sensitive to high ... #medications #pharmacology ... table #comparison #binders
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Algorithm • IV ... • Consider K+ binder ... blocks, QRS axis shift ... #potassium #high ... #treatment
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... Management of Hyperkalemia ... #Binders #Management ... #Hyperkalemia # ... treatment #pharmacology
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
Algorithm • Treat ... • Reconsider treatment ... Intracellular K+ Shift ... #treatment #potassium ... #high
KDIGO Treatment algorithm for management of acute hyperkalemia in the emergency department • Place on cardiac
KDIGO Treatment ... of acute hyperkalemia ... • Consider K+ binder ... #treatment #potassium ... #high #nephrology
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... - Hyperkalemia ( ... high potassium levels ... Because digoxin binds ... can more easily bind
Orthostatic Hypotension Management Algorithm • Hypovolemic? Yes → Resuscitate • Volume Overloaded? No → Fludrocortisone
Hypotension Management Algorithm ... Pyridostigmine Non-pharmacologic ... • Abdominal binder ... tension of the thigh ... #treatment
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
130 mEq/L • Potassium ... Is Dangerous in Hyperkalemia ... transcellular shift ... densa receives high ... NS #comparison #pharmacology
Hyperkalemia Management Pseudohyperkalemia: 1. Hemolyzed sample 2. Blood drawn from a site/line where potassium or TPN is
Hyperkalemia Management ... minutes-hour) -Shift ... dialysis • SLOW - Bind ... #Management #treatment ... #potassium #high
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