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management differential causes hyperkalemia nephrology tumor algorithm rhabdomyolysis classification hematology leukostasis paralysis periodic summary tumorlysis uricacid urine
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... 8.0 mg/dL • Potassium ... Treatment of TLS ... #TLS #diagnosis
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
patients with hypokalemia ... the basis of the potassium-to-creatinine ... creatinine) • Cell shift ... #urine #potassium ... differential #algorithm #diagnosis
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... due to cell lysis ... syndrome - Rhabdomyolysis
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... due to cell lysis ... syndrome - Rhabdomyolysis
Thyrotoxic Periodic Paralysis - Illness Script • Epidemiology: Asian men age 20-30 with hyperthyroidism of any
Thyrotoxic Periodic ... hypersensitization of the Na-K ... Labs/lmaging: Hypokalemia ... • Treatment: Potassium ... Periodic #Paralysis #diagnosis
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... ≥ 8 mg/dL • Potassium ... of the above Treatment ... Syndrome #diagnosis ... #management #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... values: Elevated K, ... hydration - Hyperkalemia ... #Syndrome #TLS ... #diagnosis #management
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... ) occur in high ... malignancies Treatments ... #Syndrome #TLS ... #oncology #management
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... Acidosis, Cell Lysis ... (TLS, rhabdo/crush ... acidosis), CK+LDH (lysis ... #Treatment #potassium
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
depletion • Consider K+ ... blocks, QRS axis shift ... #potassium #high ... #diagnosis #management ... #algorithm #treatment
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