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diagnosis differential management nephrology causes hyperkalemia algorithm rhabdomyolysis tumorlysis uricacid classification emergencies hematology hemeonc leukostasis low oncologic pathophysiology summary
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor ... Lysis Syndrome ... (TLS) and Treatment ... 8.0 mg/dL • Potassium ... Treatment of TLS
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology of Tumor ... Lysis Syndrome ... (TLS) Tumor Cell ... Lysis -> Release ... urine pH) • Hypocalcemia
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
the basis of the potassium-to-creatinine ... Urine K+ <13 mEq ... creatinine) • Cell shift ... Renin secreting tumor ... #urine #potassium
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... uric acid, LDH, Urine ... ≥ 8 mg/dL • Potassium ... of the above Treatment ... #Tumor #Lysis #
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis Syndrome ... Lysis Syndrome: ... values: Elevated K, ... hydration - Hyperkalemia ... #Lysis #Syndrome
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... Intracellular Shift ... due to cell lysis ... Transfusion reaction - Tumor ... lysis syndrome
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... ) occur in high ... malignancies Treatments ... #Lysis #Syndrome ... #TLS #oncology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... Intracellular Shift ... due to cell lysis ... Transfusion reaction - Tumor ... lysis syndrome
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
treated with IV potassium ... A urine K/Cr ratio ... • Diarrhea A urine ... urinary losses: • High ... Renin secreting tumor
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Acidosis, Cell Lysis ... (TLS, rhabdo/crush ... acidosis), CK+LDH (lysis ... ) ± Urine ... #potassium #nephrology
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