11 results
diagnosis management causes differential hyperkalemia nephrology tumor rhabdomyolysis tumorlysis uricacid classification emergencies hematology hemeonc leukostasis oncologic summary
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... 8.0 mg/dL • Potassium ... Treatment of TLS ... #management #oncology
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... Lysis -> Release ... #TLS #Pathophysiology
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... ≥ 8 mg/dL • Potassium ... of the above Treatment ... of Clinical TLS ... #management #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: • Pathophysiology ... immature blasts and high ... Syndrome: • Pathophysiology ... hydration - Hyperkalemia ... #Syndrome #TLS
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... ) occur in high ... malignancies Treatments ... #Syndrome #TLS ... #oncology #management
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... Intracellular Shift ... syndrome - Rhabdomyolysis ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... Intracellular Shift ... syndrome - Rhabdomyolysis ... #high #nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
HIV, Influenza, TSS ... Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Compartment syndrome ... HIV, Influenza, TSS ... or compartment syndrome ... Shift of extracellular ... Monitor potassium
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... antibiotics TLS ... (tumor-lysis syndrome ... low Ca - q8 h TLS ... → no immediate treatment
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