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diagnosis hyperkalemia table treatment comparison medications nephrology algorithm cardiology causes pathophysiology rhabdomyolysis agents anemia chf clinical criticalcare digoxin druginduced drugs
Key Characteristics of Old and New Potassium-Binding Agents - Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd #Potassium #Binding #KBinders #Kayexelate
of Old and New Potassium-Binding ... edgarvlermamd #Potassium ... #Binding #KBinders ... Comparison #Table #Pharmacology
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... nonspecifically binds ... of aspiration #Potassium ... #Binding #Hyperkalemia ... #medications #pharmacology
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... • Consider K+ binder ... Dialysis Serum potassium ... blocks, QRS axis shift ... #hyperkalemia #potassium
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... for Management ... cyclosilicate #Potassium ... #Binders #Management ... Hyperkalemia #treatment #pharmacology
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... works by directly binding ... the cell, serum potassium ... Because digoxin binds ... CaitEKulig #Digoxin #Pharmacology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Rhabdomyolysis - Differential ... Diagnosis and Management ... Shift of extracellular ... Monitor potassium ... #Diagnosis #Management
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
Lactated Ringers ... 130 mEq/L • Potassium ... 7.5 Lactated Ringers ... transcellular shift ... NS #comparison #pharmacology
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
• Hapten (Drug binding ... drug-antibody complex binds ... Hemolytic #Anemia #differential ... #diagnosis #pharmacology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Framework and Management ... Shift of extracellular ... Monitor potassium ... #Diagnosis #Management
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