32 results
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
Drugs associated ... Hypokalemia - Shift ... #Medications #differential ... #diagnosis #nephrology ... #Causes #hypomg
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Thyrotoxicosis Medications ... Renal Losses ... Non-renal losses ... Diagnosis #Algorithm #nephrology ... #low #potassium
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Differential Diagnosis Renal ... Causes of Hypomagnesemia ... Renal Causes of ... - Acquired: Medications ... #nephrology #magnesium
Antiarrhythmic Drugs

CLASS IA
 • Procainamide, Quinidine, Disopyramide
CLASS 1B
 • Lidocaine, Mexiletine
CLASS 2
 • Propranolol, Esmolol
CLASS 4
Antiarrhythmic Drugs ... CLASS IA • ... Adenosine, Magnesium, Potassium ... Antiarrhythmic #Medications ... #Pharmacology #
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
Causes of Hypomagnesemia ... osmotic diuresis - Potassium ... disease Drugs: ... #differential #medications ... #drugs #pharmacology
Approach to Hypomagnesemia 

Fractional excretion of magnesium = (urine magnesium x serum creatinine)/ [0.7 (serum magnesium
Approach to Hypomagnesemia ... intake, Gl loss, shift ... cells FEMg >4% = renal ... differential #diagnosis #causes ... #nephrology #magnesium
Hypokalemia Differential Diagnosis Algorithm

Low intake 
• poor oral intake 

Renal loss 
• Medication 
• Hypomagnesemia 
•
oral intake Renal ... loss • Medication ... • Hypomagnesemia ... Transcellular shift ... Diagnosis #Algorithm #Causes
Causes of Hyperkalemia

Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
Causes of Hyperkalemia ... transcellular shifts ... with impaired renal ... function, medication ... and underlying renal
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
reactions Common Drugs ... Intracellular Shift ... Medications 2. ... #potassium #high ... #nephrology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Increased EC shift ... pathophysiology #pharmacology ... #potassium #medications