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differential causes workup hemolysis hemolytic management rheumatology secondary extravascular generalized intravascular oncology pathophysiology pruritus testing acidosis activation alopecia arthritis bandemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
anemia • Cold ... Test: Donath-Landsteiner ... test #cold # ... agglutinin #disease ... #hematology #diagnosis
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... Hemolysis #Hemolytic #Anemia ... Causes #Workup #Hematology ... GrepMed Recommended Text
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... Consider sickle cell ... Agglutination - Cold agglutinins ... #hematology #testing
Mucous Membrane Disorder - Differential Diagnosis Algorithm Erosions/Ulcers/Blisters - Primary Dermatologic Diseases •
- Differential Diagnosis ... Algorithm Erosions ... Systemic lupus ... • Squamous cell ... MucousMembranes #dermatology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Diseases Nail ... Iron deficiency anemia ... #Secondary #dermatology ... #Differential #Diagnosis ... #Algorithm #causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... ) (e.g. lupus, CLL ... . primary cold agglutin ... #hematology #anemia
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Generalized Differential Diagnosis ... Algorithm - Systemic ... Liver Function Tests ... renal failure/uremia ... #generalized #dermatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Algorithm Normal ... Liver Function Tests ... #Algorithm #Causes ... #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential Diagnosis ... Algorithm Infectious ... Inflammatory • Systemic ... • Sickle Cell ... #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH ... Defects: Sickle cell ... anemia, Thalassemias ... Laboratory Tests ... #hematology
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