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differential hepatology liver hellp obstetrics pregnancy algorithm hepatitis lfts rheumatology table thrombocytopenia autoimmune chemistry disease hemolysis icp injury interpretation myopathy
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
) Three syndromes ... Elevated Liver tests ... Thrombocytopenia #TTPHUS ... #hematology #diagnosis ... #table #comparison
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
clinical symptoms/signs ... presence of metabolic syndrome ... the magnitude of enzyme ... #Algorithm #Hepatology ... #Liver #Enzymes
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Pregnancy Three syndromes ... Elevated Liver tests ... #HELLP #AFLP #Obstetrics ... #OBGyn #Hematology ... #Diagnosis #Comparison
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
necrosis HELLP Syndrome ... Elevated Liver enzymes ... of Pregnancy (AFLP ... obstetrics #hepatitis #comparison ... #differential #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... vein: Budd-chiari syndrome ... source - Tests ... function may be abnormal ... Source of Liver Enzyme
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... , Spiders - Enzyme ... Laboratory Tests ... Blood Smear ↑ abnormal ... #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Near normal ... Source of Liver Enzyme ... • Gilbert's syndrome ... liver #chemistry #diagnosis ... #differential #Hepatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
value for this enzyme ... value is low, tests ... indirect antiglobulin tests ... leukocytosis with a left shift ... #Workup #Hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... purpura: Strong sign ... Muscle strength & enzymes ... fluid (CSF) is abnormal ... #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... Tests: • Measure ... papules and Gottron sign ... ) • Shawl sign ... Anti-aminoacyl-tRNA synthetase enzymes
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