40 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
process whereas secondary ... • In secondary ... / Symptoms: - ... Xeroderma (Dry skin ... #Symptoms
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
LcSSc) - distal skin ... DcSSc; diffuse) - skin ... Hepatic: PBC (primary ... salt and pepper" skin ... changes): skin
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
== Primary Skin ... • Xerosis (dry skin ... Skin Lesion / Systemic ... Cholestatic liver disease ... #secondary #systemic
CLINICAL MANIFESTATIONS 
OF ADRENAL INSUFFICIENCY. 

Primary and secondary adrenal insufficiency:
 - Tiredness, weakness, mental depression
Primary and secondary ... Autoimmune thyroid disease ... Central nervous system ... disorders: - Pale skin ... Insufficiency #Signs
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis
Secondary Syphilis Rash
Secondary syphilis is the most contagious of all the stages of this disease, and
Rash Secondary ... stages of this disease ... characterized by a systemic ... Skin rash and malaise ... The signs and symptoms
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Joint Disorders - Differential ... arthritis - with the skin ... inflammation is secondary ... should have other symptoms ... like “butterfly rash
Stages of Syphilis
Early Primary:
 • Painless chancre
 • Regional lymphadenopathy
Early Secondary:
 • Fever, malaise
 • Rash
Syphilis Early Primary ... lymphadenopathy Early Secondary ... Fever, malaise • Rash ... lesions in bone, skin ... #signs #diagnosis
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Arthralgia/arthritis, Skin ... rash ± odynophagia ... fraction < 20% Differential ... solid cancers • Systemic ... #diagnosis #management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Eosinophilia and Systemic ... characterized by extensive skin ... rash in association ... Skin involvement ... Resolution > 15 days Differentials