37 results
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... valve lesions Abdominal ... erythematosus #signs ... #symptoms #diagnosis
Pathyophysiology - hyperglycemic crises in patients with diabetes 
Key signs/symptoms of HHS/DKA:
Both: Polyuria, polydipsia, weight loss,
hyperglycemic crises ... diabetes Key signs ... /symptoms of HHS ... hypovolemia (dry MM, skin ... , N/V, diffuse abdominal
Clinical manifestations of anaphylaxis. 
Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache
Angioedema: Lips, tongue, orbit,
intestines, extremities Skin ... (Skin and Mucosa ... intestinal edema, abdominal ... #anaphylaxis #signs ... #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... inflammation on skin ... pathophysiology #diagnosis #signs ... #symptoms #complications
Nikolsky's Sign in Toxic Epidermal Necrolysis (TEN) - See Updated MP4 Clip Here: https://www.grepmed.com/images/6837

Nikolsky's sign is
Necrolysis (TEN) - See ... rubbing of the skin ... Staphylococcal scalded skin ... syndrome, caused ... #Video #Clinical
Lymphocutaneous Sporotrichiosis Infection

Landscaper w/ painless nodular rash of arm present for months wax and wane; diagnosis?
Lymphocutaneous
painless nodular rash ... trauma leads to skin ... painless, no systemic signs ... biopsy preferred Differential ... Infection #clinical #photo
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Purpura, ischemic skin ... - Affects the skin ... Cryoglobulinemic Vasculitis - Skin ... glomerular ischemia - Skin ... Small Vessels: Skin
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Syndrome) is a skin ... inflamed or blistered skin ... development of skin ... deeper into the skin ... small samples of skin
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
for secondary causes ... organ-specific signs ... or symptoms (eg ... , skin or esophageal ... Disorders #Algorithm #Differential
Capnocytophaga Canimorsus Skin Rash

40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
Capnocytophaga Canimorsus Skin ... colonize human skin ... dogs & latter can cause ... Capnocytophaga #Canimorsus #Skin ... #clinical #photo