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diagnosis rheumatology differential erythematosus lupus sle vasculitis signs symptoms vasculitides behcet classification conditions dermatology disease dress extrarticular immune inflammatory iris
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... loss (50%) Eye: Sjögrens ... (15%) Skin (85% ... Polyneuropathy, Cranial nerve ... Demyelinating syndromes
Small Vessel Vasculitides • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
and C viruses. systemic ... erythematosus, and Sjogren's ... syndrome • IgA ... in absence of skin ... Vasculitides #vasculitis #differential
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Associated with skin ... heart block • Sjogren ... syndrome Anti-UI-ribonucleoprotein ... polymyositis overlap syndrome ... #rheumatology #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Lacrimal swelling • Skin ... myelopathy, cranial nerve ... amyloidosis, PAH Skin ... : • Dry skin (xerosis
MIAMI Mnemonic for Differential Diagnosis of Lymphadenopathy Malignancies - Kaposi sarcoma, leukemias, lymphomas, metastases, skin neoplasms Infections -
MIAMI Mnemonic for Differential ... lymphomas, metastases, skin ... rheumatoid arthritis, Sjögren ... syndrome, Still ... disease, systemic
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 Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Purpura, ischemic skin ... - Affects the skin ... Cryoglobulinemic Vasculitis - Skin ... glomerular ischemia - Skin ... Small Vessels: Skin
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Eosinophilia and Systemic ... characterized by extensive skin ... Skin involvement ... Resolution > 15 days Differentials ... SinaiBmoreIMRes #DRESS #Syndrome
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... commonly affects the skin ... • Affects the skin ... cmpkx deposits skin ... Vasculitis: • Skin
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Neurologic system ... Genitourinary system ... enlargement - Sjögren's ... Scleroderma Thickened skin ... #joint #pain #differential
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... response to local skin ... retinal damage) • Skin ... test (this is a skin ... #diagnosis #management
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