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diagnosis dermatology differential management clinical vasculitis causes scleroderma skin syndrome algorithm erythematosus lupus oncology photo signs sle symptoms treatment blanching
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
LcSSc) - distal skin ... DcSSc; diffuse) - skin ... salt and pepper" skin ... changes): skin ... Scleroderma #SSc #rheumatology
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Systemic Sclerosis ... anti-Sc170): Diffuse skin ... Anti-centromere: Limited skin ... Rapid progressive skin ... Autoantibodies #diagnosis #rheumatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Causes == Primary Skin ... • Xerosis (dry skin ... == No Primary Skin ... Cholestatic liver disease ... #generalized #dermatology
Pyoderma Gangrenosum: Autoimmune disorder resulting in a vasculitis which causes slowly progressive ulceration of the skin.
ulceration of the skin ... a number of systemic ... diseases, it is ... Clinical #Photo #Dermatology ... #SkinRash #Pyoderma
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... Sjögrens (15%) Skin ... Polyneuropathy, Cranial nerve ... pain (20%) Renal disease ... symptoms #diagnosis #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Skin Conditions ... Scleroderma Thickened skin ... arthritis Discoid skin ... #joint #pain #skin ... #diagnosis #rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Arthralgia/arthritis, Skin ... fraction < 20% Differential ... solid cancers • Systemic ... management #treatment #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Involving the Skin ... Vasculitis Skin ... Vasculitis: • Behcet Disease ... Cutaneous #Vasculitis #skin ... #dermatology #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Associated with skin ... • MCTD (SLE/systemic ... @AnnKumfer #Systemic ... Summary #diagnosis #rheumatology
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Skin manifestations ... ophtho referral • Systemic ... : • Systemic steroids ... : • Systemic steroids ... #pharmacology #rheumatology
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