10 results
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Malar rash 40% - Fever ... mimickers, Other auto-immune ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Subacute-Acute: • Common: fever ... Imaging: CXR- pulmonary ... Diagnosis: >3 symptoms ... #diagnosis #management ... #hematology #oncology
Emphysematous Cystitis
Epidemiology:
 • Usually middle-aged diabetic women
 • Other RF: neurogenic bladder, urinary tract outlet obstruction,
urinary catheter and immune ... /Symptoms: • Usually ... cystitis, may have fever ... be present or signs ... clostridium, klebsiella pneumoniae
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... Vasculitis: • Fevers ... purpura: Strong sign ... • Progressive symptoms ... Differential #Diagnosis #Rheumatology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... activity → local immune ... Pulmonary: dyspnea ... acute sarcoidosis Pulmonary ... #Signs #Symptoms
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
underlying genetic immune ... Diagnosis: HLH signs ... and symptoms can ... following: • Fever ... Lymphohistiocytosis #diagnosis #management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
cryptococcomas, cavitating pneumonia ... - Pneumonitis (fever ... leukoencephalopathy (PML ... Fever, chills, lack ... Differential #Diagnosis #Management
Cryptogenic Organizing Pneumonia - Illness Script

PATHOPHYSIOLOGY: Unknown trigger, reversible inflammatory/fibroproliferative process. Polypoid fibroblastic aggregates that plug
Males=Females SIGNS ... /SYMPTOMS: • Acute ... Cough, dyspnea, fever ... #diagnosis #management ... #pulmonary
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
rendering the immune ... with no early symptoms ... Lymphadenopathy • Fevers ... Physical Exam/Signs ... Transform to DLBCL, PML
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Necrotizing, pauci-immune ... respiratory tracts Immune ... Presentation - Systemic Symptoms ... purpura: strong sign ... differential #diagnosis #rheumatology