19 results
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
of hip (rare), Arthritis ... lesions Abdominal pain ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Approach to Joint ... or nerve root Symptoms ... #MSK #rheumatology ... #approach #workup ... #differential #
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Approach to Joint ... Pain - Arthritis ... noninflammatory Signs ... constitutional symptoms ... Joint #pain #Differential
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... heliotrope rash, Shaw sign ... , holster sign, ... anti-synthetase syndrome ... myositis, and arthritis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behcet disease) Differential ... : SLE, Reactive ... Nonsurgical abdominal pain ... diagnosis #management #signs ... #symptoms #rheumatology
Approach to Headaches - Differential Diagnosis Algorithm

Red flags (PHANTOMS):
 • Pattern change, progressively worse, papilledema
 •
Approach to Headaches ... papilledema • Horner syndrome ... • Meningeal signs ... ) • Systemic symptoms ... and signs (e.g.
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Manifestations: - Arthritis ... autoantibodies #signs ... #symptoms #mimickers ... #differential # ... rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... context of other symptoms ... , Sjögren Syndrome ... ANA #patterns #rheumatology ... #diagnosis #differential
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint ... Chronic = RA, SLE ... #rheumatology # ... approach #workup ... #differential #
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Joint pain • Swan ... Induced Lupus: • Symptoms ... Erythematosus #Diagnosis #Rheumatology