10 results
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... and AV node activity ... to prolong AV node ... #Pharmacology #Classification ... #Classes #pathophysiology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Vaughan Williams Classification ... to prolong AV node ... to prolong AV node ... #Pharmacology #Classification ... #Classes #pathophysiology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
lymphatic system (node ... are present • Classic ... Lymphoproliferative #Disorders #Classification ... #pathophysiology
Peripheral Edema - Differential Diagnosis Framework for Lower Extremity Edema

Edema occurs when any of the following
• May-Thurner Syndrome ... • SVC syndrome ... angioedema Note ... iliac vein which crosses ... #PhysicalExam #Pathophysiology
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... down both legs) Note ... #CaudaEquina #Syndrome ... #MSK #pathophysiology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... peripheral lymph nodes ... Specific sarcoidosis syndromes ... symptoms) • Löfgren syndrome ... • Heerfordt syndrome
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... Pathophysiology: ... Exclude other AKI causes ... Classification: ... #Hepatorenal #Syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... Mucocutaneous lymph node ... syndrome - Coronary ... • Cogan Syndrome ... #rheumatology #classification
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... Incidence: 1 to 2 cases ... dissociation - Of note ... the underlying pathophysiology ... Guillain #Barre #Syndrome
PFAPA Syndrome - Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis

EPIDEMIOLOGY:
PFAPA is the most common syndrome entailing
PFAPA Syndrome - ... fever (FMF) PATHOPHYSIOLOGY ... , the cervical nodes ... The classic presentation ... It causes the absolute