2020 results
Antiarrhythmics - Vaughan Williams Classification
Class I (Ia, Ib, Ic) - Na+ Channel Blockade
 • Slows depolarization
Channel Blockade • Slows ... depolarization in slow ... AP cells • Slows ... AP cells • Slow ... Classes #cardiology #pharmacology
Calcium Channel Blockers - Dihydropyridines vs Non-Dihydropyridines
Dihydropyridines (amlodipine, felodipine, nifedipine, nicardipine)
 • SVR: Decrease
 • Inotropy:
• Chronotropy: Slows ... • Dromotropy: Slows ... NonDihydropyridines #pharmacology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... open leading to slow ... of phase 4 to slow ... • MOA: Block slow ... Antiarrhythmics #Pharmacology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Strong Blockade, Slow ... of phase 4 to slow ... • MOA: Block slow ... and 4 to ↑ ERP (slow ... Vaughan #Williams #Pharmacology
OPIOID SWITCHING AND TAPERING.

Long term opioid use results in physical (and potentially psychological) dependence. Opioids should
possible by a slow ... tapering #switching #pharmacology
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... hypoglycemia • Low ... — mitigated by slow ... #Metformin #Pharmacology
Antibiotic treatment durations for first line antibiotics recommended by Public Health England (PHE) guidance
 • Acute
further 7 days if slow ... outpatient #treatment #pharmacology
Class I Antiarrhythmics and their Key Pharmacologic Properties

Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer")
Class IB
and their Key Pharmacologic ... • Slows depolarization ... Antiarrhythmics #Pharmacology
Medication Protocol for Management of Delirium in Older Adults - Always start low and go slow
Olanzapine
- Always start low ... and go slow Olanzapine ... Geriatrics #Treatment #Pharmacology
Oral Hypoglycemics in Diabetes Management
1  INSULIN SENSITIZER
 • TZD 
     -
polysaccharide degradation, slows ... Diabetes #Management #pharmacology