10 results
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
myelogenous leukemia (AML ... Clinical #Path #BloodSmear ... #Blood #Smear # ... Microscopy #Auer #Rods #AuerRods ... #AML
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
her peripheral blood ... smear showed hypogranular ... Clinical #Path #BloodSmear ... #Blood #Smear # ... Microscopy #Auer #Rods #AuerRods
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic leukemia (blood ... features in most cases ... promyelocytic #leukemia #APL ... #Hematology #Clinical ... #Smear
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
plateletcount), peripheral blood ... smear, HIV/HCV ... not required in all ... dysplasia on the smear ... #Workup #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... smear or on bone ... : Blast crises ... • Peripheral smear ... #Leukemia #Hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... Peripheral Smear ... smear • Bone marrow ... Syndromes #diagnosis #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... deficiency • blood ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
ABO incompatible blood ... protein C and S Pathophysiology ... • Peripheral smear ... Treat primary cause ... treatment #management #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... thrombosis and/or blood-brain ... (for secondary APS ... CNS #neurology #rheumatology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Caused by splanchnic ... Pathophysiology: ... , protein, or blood ... Exclude other AKI causes ... evaluation essential in all