10 results
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic leukemia (blood ... granules, and Auer rods ... features in most cases ... #Hematology #Clinical ... #Smear
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
linear red "Auer rod ... Clinical #Path #BloodSmear ... #Blood #Smear # ... Microscopy #Auer #Rods ... #AuerRods #AML
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
her peripheral blood ... smear showed hypogranular ... Clinical #Path #BloodSmear ... #Blood #Smear # ... #AuerRods #APL
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
smear or on bone ... : Blast crises ... 50-60 • Auer Rods ... • Peripheral smear ... #Leukemia #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
plateletcount), peripheral blood ... smear, HIV/HCV ... not required in all ... dysplasia on the smear ... #Workup #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... Peripheral Smear ... Out Secondary Causes ... smear • Bone marrow ... Syndromes #diagnosis #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... deficiency • blood ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... thrombosis and/or blood-brain ... (for secondary APS ... CNS #neurology #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
ABO incompatible blood ... protein C and S Pathophysiology ... • Peripheral smear ... Treat primary cause ... treatment #management #hematology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Caused by splanchnic ... Pathophysiology: ... , protein, or blood ... evaluation essential in all ... Hepatorenal #Syndrome #Hepatology