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diagnosis neurology differential causes algorithm management ocular ophthalmology ptosis summary abg acetylcholinereceptor achr acid acidbase agonists base bloodgas cholinergic clinical
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis ... the postsynaptic neuromuscular ... chewing, loss of smile ... Limb- proximal weakness ... immunologic assay - MuSK
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
• Cardio-pulmonary ... Muscular Atrophy Neuromuscular ... Oculomotor • Myasthenia ... Gravis • Lambert-Eaton ... Myasthenic Syndrome
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Weakness • Spinal ... Demyelinating Disease (MS ... Eaton Syndrome, Myasthenia ... Gravis, Organophosphate ... #Weakness #Causes
Ocular Myasthenia Gravis on Physical Exam A 41yo female was referred by her neurologist for double vision.
Gravis on Physical ... non-localized EOM weakness ... Myasthenia gravis ... tumor, and always ask ... #clinical #video
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 Drugs associated with worsening of Myasthenia Gravis (MG): • D-penicillamine • Botulinum toxin. • Telithromycin • Fluoroquinolones • Quinine • Magnesium • Macrolide antibiotics • Corticosteroids (may cause transient
with worsening of Myasthenia ... Gravis (MG): • ... Patients with MuSK-MG ... higher risk of myasthenic ... because of bulbar weakness
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... the postsynaptic neuromuscular ... or respiratory weakness ... or generalized weakness ... #Gravis #diagnosis
Ptosis - Differential Diagnosis Framework Ptosis (Greek- to fall) Drooping of the upper eyelid that usually results
Myasthenia gravis ... affecting the muscle, neuromuscular ... to ptosis and weakness ... gravis • Botulinum ... gravis • Ocular
Summary of actions of some Cholinergic Agonists Bethanechol • Used in treatment of urinary retention • Binds
Reverses CNS and cardiac ... In treatment of myasthenia ... gravis • Used ... for diagnosis of myasthenia ... gravis • Used
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
: • Non-neuromuscular ... disorder (Cardiac ... Neuromuscular Junction ... Postsynaptic: Myasthenia ... Gravis - Lack
Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm Central Nervous System - Decreased LOC, Axial
Decreased LOC, Axial Weakness ... Profound Peripheral Weakness ... Degeneration - Neuromuscular ... and Transient Myasthenia ... Gravis •
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