12 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome Pathophysiology ... nephron → - ↑ K+ ... Hypokalemia Metabolic alkalosis ... Contraction → ↑ Renin ↑ Ca ... #nephrology #diagnosis
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
A urine K/Cr ratio ... • Diarrhea A urine ... - Metabolic Alkalosis ... #Hypokalemia #diagnosis ... differential #potassium #nephrology
Hyperkalemic Distal Renal Tubular Acidosis (RTA) Type 4 - 

Failure to acidify urine in collecting duct
Failure to acidify urine ... mechanistically to K ... #Hyperkalemic #Diagnosis ... #Management #Nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
- Differential Diagnosis ... leukemia Measure Urine ... Glucose, Acute resp. alkalosis ... Fanconi syndrome, CA ... Workup #phosphate #nephrology
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
- Differential Diagnosis ... failure (uremia) K ... sedation, narcotics, CVA ... Interpretation #Diagnosis ... #Summary #Nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... and Management ... lysis) ± Urine ... Calcium 2-3g IV Ca-gluconate ... #potassium #nephrology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... permeability Diagnosis ... prevention (statin for CVA ... Erythematosus #SLE #CNS #neurology ... #management #treatment
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome - Diagnosis ... Hypomagnesemia - Metabolic Alkalosis ... Elevated Renin Urine ... Inappropriate renal K+ ... #Workup #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
• Metabolic alkalosis ... disequilibrium syndrome • Diagnosis ... irrigation • Management ... Inhibitors of Na+K+ ... Excretion #Diuresis #Nephrology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
may precede the neurologic ... Etiology: • Pathophysiology ... factor PRES Diagnosis ... narrowing on MRA/CTA ... #management #neurology