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Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
Acute Kidney Injury ... (AKI) - Differential ... : • Hypovolemia ... , Anti-GBM • Tubular ... #Diagnosis #nephrology
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
- Differential ... • Metabolic acidosis ... glycosides • High acute ... Elimination: • AKI ... #Differential #
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Prerenal:
 • Due to true volume loss or decreased
(AKI) - Differential ... blood volume • Hypovolemia ... tubular necrosis ... #Differential # ... Diagnosis #nephrology
Distal Renal Tubular Acidosis
Distal RTA is the true Nephrogenic RTA and can be truly divided into
Distal Renal Tubular ... Acidosis Distal ... variants- the hypokalemic ... ATPase - AEI ... #diagnosis #differential
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Kidney Injury AKI ... - Differential ... Impaired forward flow ... Tubular Injury/ ... #Diagnosis #nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
tobacco, Renal tubular ... acidosis, Postobstructive ... Hypomagnesemia, Acute ... #Causes #differential ... #diagnosis #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... alkalosis • Normal or low ... ratio 0.5%) Differential ... syndrome, Renal tubular ... acidosis (RTA))
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
Acidosis B. ... uropathy, post-acute ... tubular necrosis ... Drug-associated: heparin, low-molecular-weight ... #Differential #