24 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... initiation • Differential ... #management #hematology ... #oncology
Pupils: Localization in Coma
 • Small, Reactive pupils: Metabolic coma.
 • Unilateral Fixed, dilated pupil :
ICH, infarct, Opiate ... • Horner's syndrome ... Localization #Coma #Neurology ... #differential #
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
- Differential ... Hyperviscosity Syndrome ... of breath • Neurologic ... : Tumor Lysis Syndrome ... #differential #
Causes of Seizures - Differential Diagnosis Algorithm
Unprovoked - Epilepsy:
 • Focal: Simple, Complex
 • Generalized: Absence,
of Seizures - Differential ... vasoconstriction syndrome ... Neurocysticercosis, PML ... Prophyria #Seizures #Differential ... Algorithm #Causes #neurology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Capillary leak syndrome ... • Tumor lysis syndrome ... #AKI #Cancer #Oncology ... #Differential # ... Classification #Nephrology
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
Hyperviscosity Syndrome ... hyperleukocytosis (AML ... Hyperviscosity #Syndrome ... #Causes #Differential ... Diagnosis #Treatment #Management
Hyponatremia - Differential Diagnosis Algorithm
Hypovolemic - Give volume
Hypervolemic (Edematous) - Look for and treat underlying cause
Hyponatremia - Differential ... cirrhosis, nephrotic syndrome ... Disease, Meds (Opiates ... #Hyponatremia #Differential ... Algorithm #diagnosis #nephrology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... (both ALL and AML ... #Tumor #Lysis #Syndrome ... #TLS #oncology ... #management #UricAcid
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS) - Differential ... Diagnosis Neurologic-Centered ... capillary leak syndrome ... • Schnitzler syndrome ... Diagnosis #hematology #oncology
Priapism 

Secondary Causes:
Medications- intracavernosal injections, anticoagulants, PDE5 inhibitors, alpha blockers, methylphenidate, cocaine
Any hyperviscosity syndrome (SCD, leukemia,
hyperviscosity syndrome ... Priapism #Diagnosis #Management ... #Urology #Differential