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differential management aki hepatology liver toxicity acidosis aclf algorithm amiodarone chronic cirrhosis classification clozapine druginduced elderly elevation failure gastroenterology geriatrics
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis ... /HDS treatments ... for alternative causes ... dechallenge • Acute
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
Medications causing Acute ... Kidney Injury ( ... sphincter tone: • Opiates ... #pharmacology # ... differential #diagnosis
Vancomycin Associated Acute Kidney Injury • Drug induced acute kidney injury is generally defined as a
• Drug induced ... acute kidney injury ... • Treatment includes ... Vancomycin #AKI #pharmacology ... #toxicology #diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... gastroenterology #management #diagnosis
Clozapine Toxicology Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
patients who have treatment-resistant ... antipsychotic drugs ... Clozapine is known to cause ... #Toxicity #Diagnosis ... #Pharmacology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
liver or renal injury ... circulation If drugs ... before beginning treatment ... cardiac output - Acute ... peritonitis - Acute
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
cytotoxic lung injury ... starting amiodarone treatment ... pleural effusions • Acute ... toxicity (e.g., acute ... #management #Toxicology
Differential Diagnosis: New-Onset Seizure in the Elderly STRUCTURAL: • Stroke/TIA, Subdural hematoma, mass • Traumatic Brain Injury
Differential Diagnosis ... Traumatic Brain Injury ... (TBI) - Acute ... seizure threshold TOXICOLOGIC ... cardiovascular causes
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