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management differential toxicity aki nephrology acidosis algorithm amiodarone anemia aplastic aspirin classification clozapine dili druginduced elevation hematology hepatology induced kidney
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
Kidney Injury ( ... tenofovir • AIN: Beta-lactams ... sphincter tone: • Opiates ... #pharmacology # ... differential #diagnosis
Vancomycin Associated Acute Kidney Injury • Drug induced acute kidney injury is generally defined as a
• Drug induced ... acute kidney injury ... • Treatment includes ... Vancomycin #AKI #pharmacology ... #toxicology #diagnosis
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... liver or renal injury ... circulation If drugs ... Causes of Lactate ... peritonitis - Acute
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... /HDS treatments ... for alternative causes ... dechallenge • Acute ... #Diagnosis #Algorithm
Salicylate Toxicity - Diagnosis and Management Consider if: 1) Patient is hot and altered 2) You see tachypnea with
no respiratory cause ... 5) History of acute ... Alkalosis, High Lactate ... Aspirin #Toxicity #Toxicology ... #Treatment
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Differential Diagnosis ... Management Summary Causes ... - Toxins - Drugs ... Isotonic fluid/Lactated ... #Management #causes
Clozapine Toxicology Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
patients who have treatment-resistant ... antipsychotic drugs ... Clozapine is known to cause ... #Toxicity #Diagnosis ... #Pharmacology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... and petechiae Causes ... propylthiouracil) - β-lactam ... aplastic anemia Treatment ... oncology #hematology #diagnosis
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
cytotoxic lung injury ... starting amiodarone treatment ... pleural effusions • Acute ... toxicity (e.g., acute ... #management #Toxicology
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