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differential causes algorithm elevation rheumatology acidosis activation calculation chronic classification electrocardiogram erythematosus fatigue index injury kidney kidneyinjury lactate lactic lupus
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
calcineurin inhibitors (e.g ... Sympathomimetics (e.g ... decongestants) • Any drug ... anticholinergic effects (e.g ... #Medications #Drugs
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Toxic Damage (e.g ... Displacement (e.g ... methotrexate) • Drugs ... anti-HLA antibodies Drugs ... Foreign Surface (e.g
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
• Anemia • ... Anti-Depressants • Drug ... Abuse (e.g. ... Alcohol) • Drug ... Malnutrition / Drug
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g ... Marrow suppression (e.g ... . drugs, chemotherapy ... Index > 3: • Acute ... Intrinsic RBC defects (e.g
Simplified Approach to Acute Kidney Injury (AKI) 1) IS THIS AN EMERGENCY? Is there a dialysis indication
Simplified Approach to Acute ... dialysis indication (e.g ... AEIOU ) or anuria ... obstruction, Nephrotoxic drugs ... (e.g NSAlDs) 3
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... Endocrine disorders (e.g ... lymphopenia, low PLT • Anemia ... extremities Drug ... • Antihistone: Drug
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... erythematosus [SLE ... • Infection (eg ... ) • Sepsis • Drug-induced ... with leukopenia, anemia
Causes of ST Segment Elevation - Differential Diagnosis Framework STEMI: • Upsloping convex STE: "Pardee's sign" +
- Differential Diagnosis ... weeks following an acute ... Sodium-channel blocking drugs ... #cardiology #ecg ... #ekg #electrocardiogram
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
by excretion (e.g ... its metabolism (e.g ... circulation If drugs ... 30mmHg) - Severe anemia ... Alcohol • Type B2: Drugs
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