11 results
Drug-Induced Acute Kidney Injury - Sites of Action Along the Nephron

#DrugInduced #AcuteKidneyInjury #AKI #Nephrology #Pathophysiology #Pharmacology
Drug-Induced Acute ... Kidney Injury - ... the Nephron #DrugInduced ... AcuteKidneyInjury #AKI #Nephrology ... Pathophysiology #Pharmacology
Medications causing Acute Kidney Injury (AKI)
Prerenal:
 • Dehydration: Diuretics
 • Altered intrarenal autoregulation: ACEIs / ARBs,
sphincter tone: • Opiates ... decongestants) • Any drug ... #Medications #Drugs ... #pharmacology # ... differential #diagnosis
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Drugs II. ... Chronic progressive kidney ... Drug-induced hyperkalemia ... Potassium-sparing ... anti-inflammatory drugs
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... #differential #diagnosis ... pathophysiology #pharmacology ... #potassium #medications ... #druginduced
Drug Induced Kidney Injury
 • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy
 • Osmotic
Drug Induced Kidney ... Glomerular Disease: Drug ... @kdjhaveri #DrugInduced ... #differential #diagnosis ... #algorithm #nephrology
Vancomycin Associated Acute Kidney Injury

 • Drug induced acute kidney injury is generally defined as a
Injury • Drug ... 24-72 hours of drug ... Vancomycin #AKI #pharmacology ... #toxicology #diagnosis ... #management #nephrology
Numerous drugs taken by elderly persons can affect water balance by direct action on the kidney
Numerous drugs taken ... action on the kidney ... action on the kidney ... #Diagnosis #Pharmacology ... #Medications #DrugInduced
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
- Differential Diagnosis ... reactions Common Drugs ... - Metabolic acidosis ... #causes #potassium ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
- Differential Diagnosis ... reactions Common Drugs ... • Recent IV potassium ... - Metabolic acidosis ... #high #nephrology
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
Acidosis B. ... Drugs: nonsteroidal ... anti-inflammatory drugs ... Drug-associated: ... #High #Potassium