8 results
Role of Uric Acid in the Inflammation of Gout

Allopurinol, Febuxostat - Xanthine oxidase
Colchicine - Release of
Inflammation of Gout ... Allopurinol, ... inflammation #gout ... #uricacid #pathophysiology ... #pharmacology #
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Drugs that Impair ... Renal Potassium ... #Hyperkalemia #Pathophysiology ... #Pharmacology # ... Impaired #Potassium
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... differential #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
The gout drug pegloticase ... #Homeostasis #Gout ... #Pathophysiology ... #Pharmacology #
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Drugs (Statins), ... Dermatomyositis) AKI - Pathophysiology ... Monitor potassium ... Allopurinol for
Allopurinol Pharmacology Summary

Xanthine oxidase inhibitor blocking the formation of new uric acid
Initiate 1-2 days prior to
Allopurinol Pharmacology ... hypersensitivity Drug ... #Pharmacology # ... pathophysiology ... #gout #uricacid
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... efflux increases out ... repolarization CLASS 3 - Potassium ... Antiarrhythmics #Pharmacology ... Classification #Classes #pathophysiology
Medications Contributing to Dysgeusia

Antimicrobial medicines	Macrolides, fluoroquinolones, ampicillin, metronidazole, tetracycline, trimethoprim-sulfamethoxazole, amphotericin B, terbinafine and other antimycotic
other antimycotic drugs ... aripiprazole Gout ... medicines Colchicine, allopurinol ... Dysgeusia #Induced #Drugs ... Differential #Diagnosis #Pharmacology