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Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... but in severe cases ... Nephritic #Nephrotic #Syndromes
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy - Casts ... Acellular Casts ... • Hyaline Casts ... "Muddy Brown" Casts ... suggestive of nephrotic sydnrome
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic Syndrome ... nephrotic/nephritic syndromes ... hematuria (RBC casts ... Nephritic #Nephrotic #Syndrome
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
Between Nephrotic Syndrome ... and Nephritic Syndrome ... == Nephrotic Syndrome ... Red blood cell casts ... Red blood cell casts
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... breakdown of cellular casts ... heme-granular casts ... Fatty - Nephrotic syndrome ... 34t5DgJ #Urinary #Casts
There are two patterns of T-wave abnormality in Wellens’ syndrome:
-Type A = Biphasic, with initial positivity
abnormality in Wellens’ syndrome ... negativity (25% of cases ... inverted (75% of cases ... #EKG #Wellens #Syndrome
Marcus Gunn Phenomenon - Jaw Winking Syndrome

Jaw-winking syndrome is thought to be caused by abnormal innervation
- Jaw Winking Syndrome ... Jaw-winking syndrome ... Most cases are congenital ... #Jaw #Winking #Syndrome
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Crigler-Najjar syndrome ... Hereditary Cholestatic Syndromes ... Dubin-Johnson syndrome ... , Rotor syndrome ... cholestasis, and some cases
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
• Hepatorenal syndromes ... Epithelial cell casts ... Obstruction • Cast
Causes of Anterior Uveitis - Differential Diagnosis
Anterior Uveitis - 90% of cases of Uveitis
 • Inflammation
Uveitis - 90% of cases ... Posner-Schlossman Syndrome ... Behcet's, SLE, TINU syndrome ... bilateral up to 30% of cases ... HIA B27-related syndrome