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diagnosis criticalcare differential sepsis causes neurology overview sirs types candida candidemia cell cns cold criteria demyelinating diseases dry encephalopathy fungemia
Systemic Inflammatory Response Syndrome (SIRS) • Non-specific (infections vs non-infectious) • ≥2 of the following: o Temp >38°C or <36°C o HR >90 bpm o RR
Sepsis • Organ dysfunction ... Septic Shock • ... >2 mmol/L Management ... hours) • Broad-spectrum ... #sepsis #sirs #shock
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
death -> end-organ dysfunction ... Neuro: altered mental ... O2 delivery • MI ... #Classification ... #diagnosis #management
Shock Classification Shock Definition: State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
Shock Classification ... END-ORGAN DYSFUNCTION ... Hemorrhagic → leading ... #Classification ... Types #diagnosis #management
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
death -> end-organ dysfunction ... Neuro: altered mental ... O2 delivery • MI ... #Classification ... #diagnosis #management
Shock Types - Classification State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
Shock Types - Classification ... END-ORGAN DYSFUNCTION ... Hemorrhagic → leading ... #Classification ... types #diagnosis #management
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
INITIAL MANAGEMENT ... • Start broad-spectrum ... ADVANCED MANAGEMENT ... • Source control ... #Diagnosis #Management
Sepsis - Diagnosis and Management Life-threatening organ dysfunction caused by a dysregulated host response to infection SEPTIC SHOCK
Life-threatening organ dysfunction ... infection SEPTIC SHOCK ... Patients w/ septic shock ... Empiric broad spectrum ... identification and control
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Seizures • Altered mental ... Infection/Sepsis/Shock ... unclear, endothelial dysfunction ... Vascular narrowing on MRA ... Syndrome #diagnosis #management
DEMYELINATING DISEASES OF THE CENTRAL NERVOUS SYSTEM What Are Demyelinating Diseases? • Conditions that damage myelin, the protective
DISEASES OF THE CENTRAL ... Neuromyelitis Optica Spectrum ... - Symptom management ... Neuromyelitis Optica Spectrum ... bladder/bowel dysfunction
Invasive Fungal Infection (IFI) Invasive fungal infections are severe infections in which fungal pathogens invade normally sterile
stay and broad-spectrum ... include fever, organ dysfunction ... Imaging studies (CT, MRI ... when feasible Management ... therapy Source control
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