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Hemolysis Classification - Intrinsic and Extrinsic Causes Commentary: Another way to think of immune hemolysis would be
Hemolysis Classification ... and Extrinsic Causes ... reactions) - Dr ... #Classification ... #Algorithm
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
reactions Type ... Hours to Days (Hemolytic ... Anemia) Type ... hypersensitivity #reactions ... #Types #Classification
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... reticulocytes • Hemolysis ... Coombs • IgG type ... 2) LOOK FOR a cause ... Rituximab +++ 3 - Splenectomy
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
thrombocytopenia, Autoimmune Hemolytic ... Penicillin-induced drug reaction ... Dermatitis (ie. reaction ... Allergy #Allergic #Reactions ... #Types #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
hypersensitivity reactions ... Allergen-specific lgE causes ... Acute transfusion reaction ... , Haemolytic disease ... #table #classification
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic Causes ... • Transfusion reactions ... udaygulati #Hemolytic ... #classification
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... blood loss, Acute hemolysis ... syndrome, POEMS • Reaction ... Asplenia/post-splenectomy ... Exercise, Allergic reactions
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... Their Mechanisms Type ... or during hemolytic ... #Classification ... Allergy #Diagnosis #Reactions
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of ... production (eg, hemolytic ... anemias, hemolytic ... reactions, hematoma ... syndrome, drug reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Pager Summary Type ... determines blood type ... Blood Product Types ... Causes purpura & ... TRALI): Leading cause
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