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diagnosis hematology algorithm hemolytic hodgkins agglutinin atlas bloodcell chronic classification cll cold comparison disease gap globulin hemolysis leukemia lymphocytic management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
the non-Hodgkin lymphoma ... • Neutropenia, anemia ... lymphoma • Hairy ... Leukemia #diagnosis #workup ... #oncology #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
IgM associated lymphoma ... liver disease, Malignant ... lymphoma, Multiple ... RBC #Morphology #differential ... #diagnosis #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
older 50-70 • Malignant ... involvement Differential ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... organ or stem cell ... Trousseau's • Malignant ... macroangiopathic hemolytic anemia ... Catastrophic APLS BCM IM
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
hematological malignancy ... Weight loss • Anemia ... Workup: • Full ... Immunohistochemical studies (to differentiate ... #oncology #management
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... concerning for malignancy ... for workup, including ... hemolysis, deficiency anemia ... Metastatic cancer, Lymphoma
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider sickle cell ... valve, vasculitis, malignant ... Diagnosis #Algorithm #workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
malignancy (CLL ... - Monoclonal - Lymphoid ... Malignancy - ... younger pts) Differential ... sensitize red blood cells
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Workup: • Complete ... blood count with differential ... Syndromes #diagnosis #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... (HCV) • CLL & ... (-) hemolytic anemia ... #Monoclonal #Differential ... #Diagnosis #Oncology
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