54 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Presentation (Pulmonary ... symptomatology Differential ... Renal #Syndrome #differential ... #diagnosis #nephrology
Orofacial Granulomatosis - Diagnosis and Management Algorithm
Idiopathic OFG: isolated swelling of the lips, BX+ non-caseating granuloma
Melkersson-Rosenthal
facial paralysis *Differential ... Intralesional Steroid ... Intralesional Steroid ... Topical/Systemic Steroids ... Immunomodulator • Biologic (Anti-TNF
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Elevated CK, +Anti-Jo ... Elevated CK, +Anti-Jo ... , +Anti-Mi2 Polymyalgia ... myopathy • Alcohol, Steroids ... Myopathies #myopathy #differential
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... disorder (Cardiac, pulmonary ... Drugs and toxins: Steroids ... #Weakness #Differential ... #Diagnosis #neurology
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
, anti-Mi-2, anti-TIF ... -1, anti-NXP-2 ... , anti-HMGCR • ... don't respond to steroids ... Inflammatory #Myopathies #differential
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Glomerulonephritis - Differential ... Churg Strauss) Anti-GBM ... Glomerulonephritis #differential ... #diagnosis #nephrology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... Syndromes and Mimics - Differential ... Vasculitis - Anti-GBM ... Positive (ANCA + anti-GBM ... Kumfer @AnnKumfer #Pulmonary
Chronic Obstructive Pulmonary Disease (COPD)
 • COPD Definition
 • Role of PFTs
 • COPD Classification and
Chronic Obstructive Pulmonary ... antibiotics or steroids ... Antimuscarinics) - Anti-inflammatory ... #Obstructive #Pulmonary
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... With associated pulmonary ... involvement: Anti-GBM ... Glomerulonephritis #Vasculitis #differential
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
post-infectious GN Anti-Glomerular ... IF • Majority anti-neutrophil ... + • c-ANCA: anti-proteinase ... Classification #Differential ... #Diagnosis #Nephrology