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diagnosis hematology hemophagocytic hlh lymphohistiocytosis syndrome treatment alkaline alp calcium causes coagulation compartment deposition dic disease disseminated hemeonc hemorrhage hepatology
Myxedema coma and thyroid storm are thyroid emergencies associated with increased mortality. Prompt recognition of these
coma and thyroid storm ... extremely reduced or elevated ... Management of myxedema ... coma and thyroid storm ... , #hyperthyroidism
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology ICH Management: 1. Manage Blood Pressure •
Pressure (ICP) - Pathophysiology ... ICH Management ... Physiology: CO2: • Low ... Hemorrhage #ICH #elevated ... #neurosurgery #management
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Low Alkaline Phosphatase ... nephrocalcinosis • CPPD ... Wilson's disease • hypothyroidism ... collection with EDTA Pathophysiology ... intracranial pressure - Elevated
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Lysis Syndrome: • Pathophysiology ... , Elevated uric ... , Low calcium • ... TLS #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
activation and cytokine storm ... Splenomegaly • Low ... >500 ng/mL • Elevated ... soluble CD25 • Elevated ... Lymphohistiocytosis #diagnosis #management
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Deposition Disease (CPPD ... ) Pathophysiology ... calcium to form CPP ... Hyperparathyroidism • Hypothyroidism ... Rheumatology #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Prolonged PT/PTT • Low ... fibrinogen • Elevated ... protein C and S Pathophysiology ... causes #treatment #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Hyperferritinemia - Elevated ... Pathophysiology ... • Cytokine storm ... Low/absent NK-cell ... Elevated soluble
Compartment Syndrome Pearls A vicious cycle of increased pressure within a facial compartment leading to compression of
Pathophysiology: ... pressure → Blood flow ... Treatment: • Elevate ... Syndrome #diagnosis #management ... #pathophysiology
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