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diagnosis differential management algorithm anemia coagulation intravascular reactions abnormal aptt blood extravascular folate hemolysis nutrition oncology product prolonged pt purpura
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... • Folate Deficiency ... • TTP/HUS • DIC ... Diagnosis #Algorithm #Causes ... #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
marrow disease - DIC ... necrosis) • VIT K deficiency ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... effect following treatment ... malignancy • Iron deficiency ... Diagnosis #Algorithm #Causes ... #Hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Treatment of Thrombotic ... severe, ADAMTS13 deficiency ... PLEX and RTX • Short-term ... #rheumatology # ... hematology
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
and/or Folate Deficiency ... with low B12 stores ... normal tissue stores ... tissue folate stores ... Diagnosis #Nutrition #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Defects • G6PD deficiency ... • PK deficiency ... • MAHA (TTP, DIC ... #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Microcytic - Iron-deficiency ... cells - G-6-PD deficiency ... , Pulmonary emboli ... coagulopathy (DIC ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Causes include : ... Pre-analytical cause ... intravascularcoagulation (DIC ... aPTT #Prolonged #Causes ... #differential #hematology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Etiologies of Folate Deficiency ... folate that can cause ... mobilize folate stores ... depleted tissue stores ... differential #diagnosis #hematology
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency ... total body iron stores ... DharSaty #Iron #Deficiency ... Fe #diagnosis #hematology
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