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Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - ... - Compartment syndrome ... Monitor potassium ... per day until stable ... causes #treatment #nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
, Compartment syndrome ... Neuroleptic malignant syndrome ... Monitor potassium ... per day until stable ... Dialysis for severe hyperkalemia
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... K+: • Tissue injury ... Hemolysis • Rhabdomyolysis ... • Tumor lysis syndrome ... blockers - MCW Nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• Trauma/Crush injury ... • Recent IV potassium ... - Tumor lysis syndrome ... - Rhabdomyolysis ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• Trauma/Crush injury ... • Recent IV potassium ... - Tumor lysis syndrome ... - Rhabdomyolysis ... #high #nephrology
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Acute spinal cord injury ... Hyporeflexia: • Hypercalcemia ... in spinal cord injury ... differential #diagnosis #table ... #neurology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
, rhabdo/crush injury ... reabsorption) Workup ... Elimination (see Table ... Management #Treatment #potassium ... #nephrology #K
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup ... with previously stable ... or acute kidney injury ... disorders including hypokalemia ... #Hypertension #Workup
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
• Unexplained hypokalemia ... (renal potassium ... • Seizures • Rhabdomyolysis ... Supplement: • Potassium ... #diagnosis #nephrology
Rhabdomyolysis - Differential Diagnosis Framework
Rhabdomyolysis = Destruction of skeletal muscle with leakage of contents into circulation.
Rhabdomyolysis - ... Neuroleptic malignant syndrome ... Electrolytes: Hypokalemia ... Diagnosis #Causes #nephrology ... #table