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diagnosis differential systemic dermatology dermatomyositis lupus neurology pulmonary sle vasculitis aids antimda5 antimda5dm antinxp2 antinxp2dm arthritis autoantibodies autoimmune bronchiectasis central
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
effusion, Restrictive lung ... Demyelinating syndromes ... pain (20%) Renal disease ... #signs #symptoms ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Myositis 4% - Lung ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
elbows/wrists and knees ... skin thickening Signs ... (interstitial lung ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... (AQP4-lgG disease ... Systemic lupus erythematosus ... diagnosis #neurology #symptoms ... #signs
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... severity of the disease ... anti-NXP2 Abs Lung
Causes of Peripheral and Central Vertigo PERIPHERAL VERTIGO 1. Benign paroxysmal positional vertigo (BPPV) - Short-lived (typically less
Causes of Peripheral ... Long symptom-free ... (Wallenberg's syndrome ... Syndrome usually ... varying neurologic signs
Rheumatoid Arthritis - Signs and Symptoms • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans • Pulmonary:
Rheumatoid Arthritis - Signs ... Pulmonary: Parenchymal lung ... Thrombocytosis, Felty's syndrome ... Arthritis #RA #Signs ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... systemic lupus erythematosus ... Presentation - Systemic Symptoms ... purpura: strong sign ... differential #diagnosis #rheumatology
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Diagnosis Framework Disease ... • CT: Halo sign ... papules, pustules, erythematous ... Constitutional symptoms ... factor • May cause
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
inflammation Symptoms ... • Mounier-Kuhn syndrome ... Nasal polyps and signs ... in the adjacent lung ... of the affected lung
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