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diagnosis hepatology hepatitis transaminitis acutekidneyinjury aflp aki alcoholic chemistry drug druginduced fatty function gastroenterology idiosyncratic induced interpretation nephrology obgyn obstetrics
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... Chronic - ongoing ↑ LFTs ... #differential # ... gastroenterology #algorithm
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... Hepatopathy • Acute ... (>1000): • DILI ... injury) • Ischemic
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis Algorithm ... for alternative causes ... dechallenge • Acute ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... Vascular Causes ... of Acute Liver
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Unconjugated Bili ... > 90% of Total Bili ... chemistry #diagnosis #differential ... transaminitis #LFTs
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... #Injury #Differential ... #Diagnosis #Causes ... #Acute #algorithm
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... = nonspecific (nausea ... headache, malaise) → Acute ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential
Guide to Acute Kidney Injury (AKI) What to ask/look for: - HPI, PMH, full ROS
Guide to Acute Kidney ... Injury (AKI) ... - TTE/liver fxn? ... Nephrology #Diagnosis #Algorithm ... #Causes #Differential
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Algorithm Assess ... exclude other causes ... Treatment: - Acute ... kidney injury with ... HCV, DILI, HCC,
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