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diagnosis differential hepatology transaminitis algorithm elevation interpretation lactate tests acidosis arthritis causes chemistry classification dehydrogenase drug elevated functiontest gastroenterology hepatitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Tests (LFTs) - ... Hepatopathy • Acute ... (>1000): • DILI ... injury) • Ischemic
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Calculate R-Value
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... Values and Interpretation ... hepatocellular injury ... #LFTs #Laboratory
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... abnormality vs bone Bili ... ALP ≥ 2x ULN R Value ... #FunctionTest #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Liver Injury: ... Liver Injury: ... • Iatrogenic: DILI ... Tests of synthetic function
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... of cholestatic disease ... disease: > 2 ... transaminitis #LFTs
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
RBCs, muscle, liver ... - Prosthetic valves ... : • Early acute ... hepatitis • Acute ... differential #diagnosis #Laboratory
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
to bolus these values ... presentations and disease ... or renal injury ... - assess other laboratory ... Injury: • Reduced
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
more time for the laboratory ... Screening Tests for Acute ... profile, including liver ... function tests ... (LFTs) and a serum
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