16 results
Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS)
Absolute Insulin deficit:
 - Type I DM:
Pathophysiology ... deficit: - Type I DM ... produced - Type II DM ... pts under large stresses ... to insulin TX, stresses
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
yrs old; F>M Signs ... palpation - Vasculitic ... Temporal #Arteritis #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Vasculitis
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis (DM ... Dermatomyositis #DM ... PM #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Vasculitis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
the pancreas, Vasculitis ... Complications #pathophysiology ... #signs #symptoms
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Inflammatory: Vasculitis ... polyneuropathy: DM ... Mononeuritis multiplex (DM ... , Vasculitis-polyarteritis ... Lack of UMN/LMN signs
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
blood vessels (vasculitis ... RA inflammation tends ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Leukocytoclastic vasculitis ... #HSP #IgA #Vasculitis ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs
Reactive Arthritis
 • Inflammation of joints (commonly large joints)
    - Asymmetric Oligoarthritis: Joint
pustules of the glans penis ... ReactiveArthritis #pathophysiology ... #diagnosis #signs
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
PolyarteritisNodosa #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Vasculitis
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... scrotum & enlarged penis ... may look like a penis ... #21HydroxylaseDeficiency #21OHD #pathophysiology