11 results
Epidemiological Clues That May be Helpful in Defining the Etiological Diagnosis of Culture-Negative Endocarditis

#Endocarditis #Bacteria #Differential
Epidemiological Clues ... Etiological Diagnosis of Culture-Negative ... #Endocarditis #Bacteria ... #Differential # ... Microorganisms #Clues
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
with Infective Endocarditis ... therapy - Number one cause ... of culture negative ... this be a non-bacterial ... #Diagnosis #Management
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
culture negative ... under BCNIE, these bacteria ... identified with modern culture ... #differential # ... #culture #negative
Primary and Secondary Causes of Mitral Regurgitation
Primary (organic) chronic mitral regurgitation:
 • Leaflet: Rheumatic fever, Infective
), Spontaneous rupture ... infarction, Tendineae rupture ... Papillary muscle rupture ... Regurgitation #differential ... #diagnosis #cardiology
Streptocccus Pneumoniae
Microbiology: Gram Positive, Alpha-hemolytic, Catalase Negative
Epidemiology - 10% adult carriers:
 • Most common cause of:
Alpha-hemolytic, Catalase Negative ... • Most common cause ... media • Important cause ... sinus • Sputum culture ... microbiology #diagnosis #management
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... but important causes ... identified with modern culture ... - Standard culture ... #diagnosis #differential
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Culture (+): ... • Coagulase-negative ... staphylococci Culture ... #diagnosis #management ... #cardiology
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
and Differential ... Culture Positive ... staphylococci Culture ... • Persistent bacteremia ... Diagnosis #cardiology
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
in 60%-90% • Culture ... in 70%-85% • Negative ... Monocytogenes or gram negative ... pneumoniae antigen detection ... by CSF or urine culture
Causes of Primary and Functional Mitral Regurgitation (MR) 
Causes of primary mitral regurgitation
 - Rheumatic heart
Infective/marantic endocarditis ... MV chordae may rupture ... laterally from myocardial ... Primary #Functional #Differential ... #Diagnosis #Cardiology