11 results
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
with Infective Endocarditis ... therapy - Number one cause ... of culture negative ... #Diagnosis #Management ... #Algorithm
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
culture negative ... under BCNIE, these bacteria ... identified with modern culture ... #differential # ... #culture #negative
Primary and Secondary Causes of Mitral Regurgitation
Primary (organic) chronic mitral regurgitation:
 • Leaflet: Rheumatic fever, Infective
), Spontaneous rupture ... infarction, Tendineae rupture ... Papillary muscle rupture ... Regurgitation #differential ... #diagnosis #cardiology
Systolic Murmurs - Differential Diagnosis Algorithm
Benign / Flow / Hyperdynamic:
 • Pregnancy
 • Fever
 • Anemia
Supravalvular
Diagnosis Algorithm ... Chordae Tendinae • Rupture ... • Infarct • Rupture ... Systolic #Murmurs #Cardiology ... #causes
Streptocccus Pneumoniae
Microbiology: Gram Positive, Alpha-hemolytic, Catalase Negative
Epidemiology - 10% adult carriers:
 • Most common cause of:
Alpha-hemolytic, Catalase Negative ... • Most common cause ... sinus • Sputum culture ... Specificity of 97%) Treatment ... microbiology #diagnosis #management
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Involves aortic and mitral ... Culture (+): ... • Coagulase-negative ... staphylococci Culture ... #cardiology
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
involves aortic and mitral ... Culture Positive ... staphylococci Culture ... • Persistent bacteremia ... Diagnosis #cardiology
Causes of Primary and Functional Mitral Regurgitation (MR) 
Causes of primary mitral regurgitation
 - Rheumatic heart
Infective/marantic endocarditis ... MV chordae may rupture ... laterally from myocardial ... #Functional #Differential ... #Diagnosis #Cardiology
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
in 60%-90% • Culture ... in 70%-85% • Negative ... Monocytogenes or gram negative ... pneumoniae antigen detection ... by CSF or urine culture
Peripartum Cardiomyopathy - Summary
1. Definition
 • Towards the end of pregnancy to 5 months postpartum
exclude other causes ... Differential Diagnosis ... recommend against future ... • During a future ... #cardiology #treatment