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differential ana antinuclear associations autoantibodies classification diseases vasculitis cryoglobulinemia cryoglobulins erythematosus management myopathy myositis patterns polychondritis relapsing sle systemic types
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Syndrome: Anti-cardiolipin ... LAC) • Sjogren Syndrome ... Autoantibodies #Rheumatology ... #table
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... cases • Sjögren syndrome ... #ANCA #Antineutrophil ... #antibodies #diagnosis ... #rheumatology #
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anticentromere - CREST syndrome ... La) - Sjogren's syndrome ... Goodpasture's syndrome ... #table #rheumatology ... #antibodies
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... Positive ANA ≠ Autoimmune ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #rheumatology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
dermatomyositis, Sjogren syndrome ... lymphoma • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome ... #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... Cryoglobulinemia Syndrome ... 20% Sjögren's syndrome ... DDX: • ANCA (Antineutrophil ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Mucocutaneous lymph node syndrome ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... purpura: strong sign ... #rheumatology #
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Antisynthetase syndrome ... lymphoma Overlap Syndrome ... ANTI-SYNTHETASE SYNDROME ... paraneoplastic syndrome ... Myositis #Myopathy #rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
common • Sjogren’s syndrome ... • MAGIC syndrome ... • Vexus syndrome ... Nodosa, GCA, Sweet syndrome ... Polychondritis #rheumatology
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