13 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
s Syndrome: Pathogenesis ... accompanies other autoimmune ... like rheumatoid arthritis ... erythematosus (SLE) Signs ... Pathophysiology #Diagnosis #Signs
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary ... quadrant discomfort Signs ... of associated autoimmune ... Raynaud's phenomenon, arthritis ... Diagnosis #Algorithm #hepatology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... heliotrope rash, Shaw sign ... , holster sign, ... anti-synthetase syndrome ... myositis, and arthritis
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... SLE), Sjogren's Syndrome ... , Sjögren Syndrome ... Hepatitis, Primary ... ANA #patterns #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome ... SLE, Reactive arthritis ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Myasthenia Gravis is an autoimmune ... , rheumatoid arthritis ... test - Cogan sign ... - Peek sign ... Gravis #diagnosis #management
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Vaginal dryness • Primary ... Nephrogenic DI Hematologic ... Arthralgia and Arthritis ... Diagnosis #Management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
disease • Non-autoimmune ... Malignancy (e.g. hematologic ... the context of primary ... deficiencies • Autoimmune ... vein thrombosis Hematologic
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Sclerosis (MS) is an autoimmune-mediated ... • Or brainstem syndromes ... • Lhermitte’s sign ... Progressive MS • Primary ... sclerosis #diagnosis #management
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... with GCA or as primary ... Primary Angiitis ... nose, tracheal collapse ... vasculitis • Cogan syndrome