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diagnosis differential pathophysiology algorithm pharmacology physicalexam management clinical diabetes video causes hypocalcemia sign signs hypothyroidism comparison dm2 symptoms adrenal hyperthyroidism
Steroid Synthesis Pathway Dr. Caoimhe Costigan @CaoimheCostigan #Steroid #Synthesis #pathophysiology #algorithm #endocrinology
Steroid Synthesis ... CaoimheCostigan #Steroid #Synthesis ... pathophysiology #algorithm #endocrinology
Steroid Synthesis Pathway (OH, hydroxy; HSD, hydroxysteroid dehydrogenase; DHEA, dehydroepiandrosterone; pink, common enzymes affecting CAH, purple –
Steroid Synthesis ... CaoimheCostigan #Steroid #Synthesis ... pathophysiology #endocrinology
Insulin and Glucagon Pathophysiology Insulin: • Glucose utilization (Glycolysis) • Glucose storage (Glycogenesis) • Fat synthesis
Glycogenesis) • Fat synthesis ... Lipogenesis) • Protein synthesis ... Actions: • Glucose synthesis ... Pathophysiology #endocrinology
Vitamin D Metabolism Fat-soluble vitamin Sources: dermal synthesis and food (dairy products, fish) Active form: calcitriol (1,25-OH Vitamin D) Main
Sources: dermal synthesis ... VitaminD #Metabolism #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
expression/protein synthesis ... #FeedbackLoop #endocrinology
Calcium homeostasis is a process controlled by chiefly by hormones vitamin D and PTH. Vitamin D
circulation via synthesis ... Pathophysiology #Endocrinology
Amiodarone Thyroid Complications Amiodarone: - iodine-rich, similar structure to T4, with half life up to 100d
thyroid hormone synthesis ... Complications #endocrinology
Causes of Hypocalcemia - Differential Diagnosis Decreased calcium absorption • Vitamin D deficiency -
- Decreased synthesis ... Diagnosis #Causes #endocrinology
Pharmaceutical Management of Hyperthyroidism / Thyroid Storm Beta-Blockers • Decreases sympathetic hyperactivity • Partially blocks peripheral conversion
PTU) • Blocks synthesis ... Methimazole • Blocks synthesis ... Administer only after synthetic
Primary Adrenal Insufficiency: • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
stimulation test - Synthetic ... diagnosis #testing #endocrinology
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