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nephrology diagnosis biomarkers definitions differential framework hepatorenal hrs hrsaki hrsckd hrsnaki hyperphosphatemia laboratory nsaids pharmacology phosphate prostaglandins syndrome workup
Definitions of AKI, CKD, AKD Acute Kidney Injury (AKI): • Increase in SCr by 2 50% within
, CKD, AKD Acute ... • GFR < 60 ml/min ... • GFR < 60 ml ... • Decrease in GFR ... • GFR ≥ 60 ml/min
Interpreting Kidney Biomarkers ↑ Creatinine: • AKI, CKD • Medications that lead to nephroprotective ↓ in
Creatinine: • AKI ... , CKD • Medications ... nephroprotective ↓ in GFR ... , CKD • Obesity ... hyperthyroidism ↓ eGFR
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
Diagnostic Criteria HRS-AKI ... Type 2) • HRS-AKD ... months - eGFR ... ascites • HRS-CKD ... - eGFR < 60ml
Effects of Prostaglandins and NSAIDs on the Kidney Effects of Prostaglandins on the Kidney: • The vasodilatory
is increased in CKD ... maintaining baseline GFR ... setting of modest GFR ... with GFR > 30 and ... avoidance with GFR
Workup for Hyperphosphatemia - Differential Diagnosis Framework Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
t-PA, heparin Acute ... Disease: • AKI ... , CKD Increased ... Renal Phosphate ... Hypoparathyroidism, Acromegaly, FGFR
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