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hyperkalemia potassium antiarrhythmics cardiology classes classification comparison diagnosis nephrology pathophysiology binder binders binding differential facial kbinder kidney lactated lr management
Effects of Prostaglandins and NSAIDs on the Kidney Effects of Prostaglandins on the Kidney: • The vasodilatory
Effects of Prostaglandins ... retention of Na, K ... is increased in CKD ... prolonged NSAID use in CKD ... renal #nephrology #pharmacology
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
15 g QD • Side Effects ... : Edema (mild to ... 8.4 g • Side Effects ... daily • Side Effects ... #medications #pharmacology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
trial • Minimal K ... - Protective effects ... • Increases Edema ... NS #comparison #pharmacology ... #effects
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... to balance out K+ ... channel blocking effects ... Fast Action, ↓ EFR ... Antiarrhythmics #Pharmacology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
esp w oliguria / GFR ... Labs: BMP (Assess GFR ... VBG (acidosis), CK ... status to improve GFR ... caution in HTN & edema
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
channel blocking effects ... Fast Action, ↓ EFR ... Slow Action, ←→ EFR ... • MOA: Block K+ ... Vaughan #Williams #Pharmacology
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
needed, based on K ... patients with CKD ... Most common side effect ... #Hyperkalemia #Pharmacology
Facial Swelling - Differential Diagnosis Framework for Facial Edema Infectious: • Dental abscess • Ludwig's angina • Vincent's angina • Cellulitis •
Framework for Facial Edema ... Contact dermatitis (CD ... • Solid facial edema ... carcinoma • Multiple myeloma ... Differential #Diagnosis #PhysicalExam
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