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hyperkalemia diagnosis nephrology differential antiarrhythmics cardiology causes classes classification comparison high pathophysiology binder binders binding effects facial kbinder kidney lactated
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia: • CKD ... transfusion • HTN and edema ... • Digoxin • K ... • Recent IV potassium ... diagnosis #causes #potassium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia: • CKD ... transfusion • HTN and edema ... • Digoxin • K ... • Recent IV potassium ... diagnosis #causes #potassium
Effects of Prostaglandins and NSAIDs on the Kidney Effects of Prostaglandins on the Kidney: • The vasodilatory
retention of Na, K ... is increased in CKD ... prolonged NSAID use in CKD ... with GFR > 30 and ... renal #nephrology #pharmacology
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... desired serum K ... Side Effects: Edema ... of aspiration #Potassium ... #medications #pharmacology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
esp w oliguria / GFR ... Labs: BMP (Assess GFR ... VBG (acidosis), CK ... caution in HTN & edema ... Management #Treatment #potassium
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... to balance out K+ ... Fast Action, ↓ EFR ... repolarization CLASS 3 - Potassium ... Antiarrhythmics #Pharmacology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
130 mEq/L • Potassium ... trial • Minimal K ... • Increases Edema ... volume - increased edema ... NS #comparison #pharmacology
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
) MECHANISM: Potassium ... needed, based on K ... patiromer) is a potassium ... patients with CKD ... #Hyperkalemia #Pharmacology
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
Fast Action, ↓ EFR ... Slow Action, ←→ EFR ... repolarization CLASS 3 - Potassium ... • MOA: Block K+ ... Vaughan #Williams #Pharmacology
Facial Swelling - Differential Diagnosis Framework for Facial Edema Infectious: • Dental abscess • Ludwig's angina • Vincent's angina • Cellulitis •
Framework for Facial Edema ... Contact dermatitis (CD ... • Solid facial edema ... carcinoma • Multiple myeloma ... Differential #Diagnosis #PhysicalExam
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